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Antinociceptive Activity of Thiazole-containing Cyclized DAMGO and Leu-(Met) Enkephalin Analogs
Numerous studies demonstrate the promise of opioid peptides as analgesics, but poor oral bioavailability has limited their therapeutic development. This study sought to increase the oral bioavailability of opioid peptides by cyclization, using Hantzsch-based macrocyclization strategies to produce tw...
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| Publicado no: | Org Biomol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6637423/ https://ncbi.nlm.nih.gov/pubmed/31094391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9ob00882a |
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