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Antinociceptive Activity of Thiazole-containing Cyclized DAMGO and Leu-(Met) Enkephalin Analogs

Numerous studies demonstrate the promise of opioid peptides as analgesics, but poor oral bioavailability has limited their therapeutic development. This study sought to increase the oral bioavailability of opioid peptides by cyclization, using Hantzsch-based macrocyclization strategies to produce tw...

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Bibliografiske detaljer
Udgivet i:Org Biomol Chem
Main Authors: Harris, Hannah M., Eans, Shainnel O., Ganno, Michelle L., Davis, Jennifer C., Dooley, Colette T., McLaughlin, Jay P., Nefzi, Adel
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637423/
https://ncbi.nlm.nih.gov/pubmed/31094391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9ob00882a
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