Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines

[Image: see text] The hypothesis in the current study is that the simultaneous direct in vivo testing of thousands to millions of systematically arranged mixture-based libraries will facilitate the identification of enhanced individual compounds. Individual compounds identified from such libraries m...

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Detalhes bibliográficos
Publicado no:ACS Comb Sci
Main Authors: Houghten, Richard A., Ganno, Michelle L., McLaughlin, Jay P., Dooley, Colette T., Eans, Shainnel O., Santos, Radleigh G., LaVoi, Travis, Nefzi, Adel, Welmaker, Greg, Giulianotti, Marc A., Toll, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710894/
https://ncbi.nlm.nih.gov/pubmed/26651386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.5b00126
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