Identification, Structure-Activity Relationships and Molecular Modeling of Potent Triamine and Piperazine Opioid Ligands

Opioid receptors are important targets for pain management. Here, we report the synthesis and biological evaluation of three positional scanning combinatorial libraries, consisting of linear triamines and piperazines. A highly potent (14 nM) and selective (IC(50(μ))/IC(50(κ)) = 71; IC(50(δ))/IC(50(κ...

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Main Authors: Yongye, Austin B., Appel, Jon R., Giulianotti, Marc A., Dooley, Colette T., Medina-Franco, Jose L., Nefzi, Adel, Houghten, Richard A., Martínez-Mayorga, Karina
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746904/
https://ncbi.nlm.nih.gov/pubmed/19576786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.06.026
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