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Conformation-Opioid Activity Relationships of Bicyclic Guanidines from 3D Similarity Analysis
Conformation of bicyclic guanidines with kappa opioid receptor activity derived in our laboratory from a positional scanning synthetic combinatorial library is presented in this work. We propose a common bioactive conformation and putative pharmacophoric features by means of 3D similarity methods. O...
में बचाया:
| मुख्य लेखकों: | , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2008
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2533277/ https://ncbi.nlm.nih.gov/pubmed/18468907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.04.061 |
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