Rapid Scanning Structure-Activity Relationships in Combinatorial Data Sets: Identification of Activity Switches

We present a general approach to describe the structure-activity relationships (SAR) of combinatorial data sets with activity for two biological endpoints with emphasis on the rapid identification of substitutions that have a large impact on activity and selectivity. The approach uses Dual-Activity...

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Main Authors: Medina-Franco, José L., Edwards, Bruce S., Pinilla, Clemencia, Appel, Jon R., Giulianotti, Marc A., Santos, Radleigh G., Yongye, Austin B., Sklar, Larry A., Houghten, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715655/
https://ncbi.nlm.nih.gov/pubmed/23705689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci400192y
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