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In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands

The use of combinatorial libraries for the identification of novel opiate and related ligands in opioid receptor assays is reviewed. Case studies involving opioid assays used to demonstrate the viability of combinatorial libraries are described. The identification of new opioid peptides composed of...

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Main Authors: Houghten, Richard A., Dooley, Colette T., Appel, Jon R.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231577/
https://ncbi.nlm.nih.gov/pubmed/16796388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/BF02854908
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