Novel Pyrrolidine Diketopiperazines Selectively Inhibit Melanoma Cells via Induction of Late-Onset Apoptosis

[Image: see text] A common liability of cancer drugs is toxicity to noncancerous cells. Thus, molecules are needed that are potent toward cancer cells while sparing healthy cells. The cost of traditional cell-based HTS is dictated by the library size, which is typically in the hundreds of thousands...

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Hauptverfasser: Onwuha-Ekpete, Lillian, Tack, Lisa, Knapinska, Anna, Smith, Lyndsay, Kaushik, Gaurav, LaVoi, Travis, Giulianotti, Marc, Houghten, Richard A., Fields, Gregg B., Minond, Dmitriy
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983399/
https://ncbi.nlm.nih.gov/pubmed/24471466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4019542
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