Glycosylation of A Disintegrin And Metalloprotease 17 (ADAM17) Affects its Activity and Inhibition

ADAM17 is believed to be a tractable target in various diseases including cancer and rheumatoid arthritis; however, it is not known whether glycosylation of ADAM17 expressed in healthy cells differs from the one found in a diseased tissue and, if so, whether glycosylation affects inhibitor binding....

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Bibliografiska uppgifter
I publikationen:Anal Biochem
Huvudupphovsmän: Chavaroche, Anais, Cudic, Mare, Giulianotti, Marc, Houghten, Richard A., Fields, Gregg B., Minond, Dmitriy
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334441/
https://ncbi.nlm.nih.gov/pubmed/24361716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2013.12.018
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