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Novel Approaches and Challenges of Discovery of Exosite Modulators of a Disintegrin and Metalloprotease 10
A disintegrin and metaproteinase 10 is an important target for multiple therapeutic areas, however, despite drug discovery efforts by both industry and academia no compounds have reached the clinic so far. The lack of enzyme and substrate selectivity of developmental drugs is believed to be a main o...
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| Publicado en: | Front Mol Biosci |
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| Autor Principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Frontiers Media S.A.
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7218085/ https://ncbi.nlm.nih.gov/pubmed/32435655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00075 |
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