SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes

ADAM17 is implicated in several debilitating diseases. However, drug discovery efforts targeting ADAM17 have failed due to the utilization of zinc-binding inhibitors. We previously reported discovery of highly selective nonzinc-binding exosite-targeting inhibitors of ADAM17 that exhibited not only e...

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Publié dans:J Med Chem
Auteurs principaux: Knapinska, Anna M., Dreymuller, Daniela, Ludwig, Andreas, Smith, Lyndsay, Golubkov, Vladislav, Sohail, Anjum, Fridman, Rafael, Giulianotti, Marc, LaVoi, Travis M., Houghten, Richard A, Fields, Gregg B., Minond, Dmitriy
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5420329/
https://ncbi.nlm.nih.gov/pubmed/26192023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00354
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