Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies

[Image: see text] Nicotine binds to nicotinic acetylcholine receptors (nAChR), which can exist as many different subtypes. The α4β2 nAChR is the most prevalent subtype in the brain and possesses the most evidence linking it to nicotine seeking behavior. Herein we report the use of mixture based comb...

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Detalhes bibliográficos
Main Authors: Wu, Jinhua, Zhang, Yaohong, Maida, Laura E., Santos, Radleigh G., Welmaker, Gregory S., LaVoi, Travis M., Nefzi, Adel, Yu, Yongping, Houghten, Richard A., Toll, Lawrence, Giulianotti, Marc A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106133/
https://ncbi.nlm.nih.gov/pubmed/24274400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401543h
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