Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency

[Image: see text] Central nervous system (CNS) neurons typically fail to regrow their axons after injury. Injuries or neuropathies that damage CNS axons and disrupt neuronal circuitry often result in permanent functional deficits. Axon regeneration is therefore an intensely pursued therapeutic strat...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Al-Ali, Hassan, Debevec, Ginamarie, Santos, Radleigh G., Houghten, Richard A., Davis, Jennifer C., Nefzi, Adel, Lemmon, Vance P., Bixby, John L., Giulianotti, Marc A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187400/
https://ncbi.nlm.nih.gov/pubmed/30344917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00425
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