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A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries

A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride in order to produce equal...

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Detalhes bibliográficos
Main Authors: Giulianotti, Marc A., Debevec, Ginamarie, Santos, Radleigh G., Maida, Laura E., Chen, Wenteng, Ou, Lili, Yu, Yongping, Dooley, Colette T., Houghten, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3825827/
https://ncbi.nlm.nih.gov/pubmed/22913403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co300060s
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