Synthesis and Characterization of a Dual Kappa-Delta Opioid Receptor Agonist Analgesic Blocking Cocaine Reward Behavior

3-Iodobenzoyl naltrexamine (IBNtxA) is a potent analgesic belonging to the pharmacologically diverse 6β-amidoepoxymorphinan group of opioids. We present the synthesis and pharmacological evaluation of five analogs of IBNtxA. The scaffold of IBNtxA was modified by removing the 14-Hydroxy group, incor...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Váradi, András, Marrone, Gina F., Eans, Shainnel O., Ganno, Michelle L., Subrath, Joan J., Rouzic, Valerie Le, Hunkele, Amanda, Pasternak, Gavril W., McLaughlin, Jay P., Majumdar, Susruta
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651729/
https://ncbi.nlm.nih.gov/pubmed/26325040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00153
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