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MP1104, a mixed kappa-delta opioid receptor agonist has anti-cocaine properties with reduced side-effects in rats

Kappa opioid receptor (KOPr) agonists have preclinical anti-cocaine and antinociceptive effects. However, adverse effects including dysphoria, aversion, sedation, anxiety and depression limit their clinical development. MP1104, an analogue of 3-iodobenzoyl naltrexamine, is a potent dual agonist at K...

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Detalhes bibliográficos
Publicado no:Neuropharmacology
Main Authors: Atigari, Diana V., Uprety, Rajendra, Pasternak, Gavril W., Majumdar, Susruta, Kivell, Bronwyn M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6585989/
https://ncbi.nlm.nih.gov/pubmed/30768946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.02.010
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