Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents

The acute activation of kappa opioid receptors (KOPr) produces antinociceptive and anti-cocaine effects, however, their side-effects have limited further clinical development. Mesyl Sal B is a potent and selective KOPr analogue of Salvinorin A (Sal A), a psychoactive natural product isolated from th...

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Publicado en:Molecules
Main Authors: Kivell, Bronwyn M., Paton, Kelly F., Kumar, Nitin, Morani, Aashish S., Culverhouse, Aimee, Shepherd, Amy, Welsh, Susan A., Biggerstaff, Andrew, Crowley, Rachel S., Prisinzano, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222496/
https://ncbi.nlm.nih.gov/pubmed/30314288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23102602
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