Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction

[Image: see text] We report a novel approach to synthesize carfentanil amide analogues utilizing the isocyanide-based four-component Ugi multicomponent reaction. A small library of bis-amide analogues of carfentanil was created using N-alkylpiperidones, aniline, propionic acid, and various aliphatic...

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Publicado en:ACS Chem Neurosci
Autores principales: Váradi, András, Palmer, Travis C., Haselton, Nathan, Afonin, Daniel, Subrath, Joan J., Le Rouzic, Valerie, Hunkele, Amanda, Pasternak, Gavril W., Marrone, Gina F., Borics, Attila, Majumdar, Susruta
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641535/
https://ncbi.nlm.nih.gov/pubmed/26148793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00137
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