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Genetic dissociation of morphine analgesia from hyperalgesia

Morphine is the prototypic mu opioid, producing its analgesic actions through traditional 7 transmembrane domain (7TM) G-protein coupled receptors generated by the mu opioid receptor gene (Oprm1). However, the Oprm1 gene undergoes extensive alternative splicing to yield three structurally distinct s...

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Detalhes bibliográficos
Publicado no:Psychopharmacology (Berl)
Main Authors: Marrone, Gina F., Le Rouzic, Valerie, Varadi, Andras, Xu, Jin, Rajadhyaksha, Anjali M., Majumdar, Susruta, Pan, Ying-Xian, Pasternak, Gavril W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520541/
https://ncbi.nlm.nih.gov/pubmed/28343361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-017-4600-2
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