Nonpeptide Small Molecule Agonist and Antagonist Original Leads for Neuropeptide FF1 and FF2 Receptors

[Image: see text] Neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R), and their endogenous ligand NPFF, are one of only several systems responsible for mediating opioid-induced hyperalgesia, tolerance, and dependence. Currently, no small molecules displaying good affinity or selectivity for ei...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Journigan, V. Blair, Mésangeau, Christophe, Vyas, Neha, Eans, Shainnel O., Cutler, Stephen J., McLaughlin, Jay P., Mollereau, Catherine, McCurdy, Christopher R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234442/
https://ncbi.nlm.nih.gov/pubmed/25268943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500989n
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