Bioanalytical method development and validation of MES207, a neuropeptide FF receptor antagonist, and its application in preclinical pharmacokinetics

The nonpeptide small molecule, MES207, exhibits 17-fold preferential binding to the neuropeptide FF receptor 1 (NPFFR1) over NPFFR2 and shows antagonist functionality at NPFF receptors. In order to further the development of MES207 as a NPFFR1 probe, an UPLC-MS/MS bioanalytical method was developed...

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Detalhes bibliográficos
Publicado no:J Chromatogr B Analyt Technol Biomed Life Sci
Main Authors: King, Tamara I., Roewekamp, Ann-Cathrin, Sharma, Abhisheak, Harrison, Sydney, Mesangeau, Christophe, Mottinelli, Marco, Kamble, Shyam H., McCurdy, Christopher R., Avery, Bonnie A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027589/
https://ncbi.nlm.nih.gov/pubmed/31790916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2019.121875
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