Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain

Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of this study was to investigate the in vivo analgesic and anti-allodynic activity of two novel sigma receptor antagonis...

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Udgivet i:Front Pharmacol
Main Authors: Cirino, Thomas J., Eans, Shainnel O., Medina, Jessica M., Wilson, Lisa L., Mottinelli, Marco, Intagliata, Sebastiano, McCurdy, Christopher R., McLaughlin, Jay P.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586922/
https://ncbi.nlm.nih.gov/pubmed/31258480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00678
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