Kratom alkaloids, natural and semi-synthetic, show less physical dependence and ameliorate opioid withdrawal

Chronic administration of opioids produces physical dependence and opioid-induced hyperalgesia. Users claim the Thai traditional tea “Kratom” and component alkaloid mitragynine ameliorate opioid withdrawal without increased sensitivity to pain. Testing these claims, we assessed the combined Kratom a...

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Pubblicato in:Cell Mol Neurobiol
Autori principali: Wilson, Lisa L., Chakraborty, Soumen, Eans, Shainnel O., Cirino, Thomas J., Stacy, Heather M., Simons, Chloe A., Uprety, Rajendra, Majumdar, Susruta, McLaughlin, Jay P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8164968/
https://ncbi.nlm.nih.gov/pubmed/33433723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10571-020-01034-7
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