The Macrocyclic Peptide Natural Product CJ-15,208 is Orally Active and Prevents Reinstatement of Extinguished Cocaine Seeking Behavior()

The macrocyclic tetrapeptide natural product CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) exhibited both dose-dependent antinociception and kappa opioid receptor (KOR) antagonist activity after oral administration. CJ-15,208 antagonized a centrally administered KOR selective agonist, providing strong eviden...

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Detalhes bibliográficos
Main Authors: Aldrich, Jane V., Senadheera, Sanjeewa N., Ross, Nicolette C., Ganno, Michelle L., Eans, Shainnel O., McLaughlin, Jay P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879116/
https://ncbi.nlm.nih.gov/pubmed/23327691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np300697k
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