The in Vitro – in Vivo Translation of Lipid Nanoparticles for Hepatocellular siRNA Delivery

par Whitehead, Kathryn A., Matthews, Jonathan, Chang, Philip H., Niroui, Farnaz, Dorkin, J. Robert, Severgnini, Mariano, Anderson, Daniel G.
Publié 2012

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

par Oberli, Matthias A., Reichmuth, Andreas M., Dorkin, J. Robert, Mitchell, Michael J., Fenton, Owen S., Jaklenec, Ana, Anderson, Daniel G., Langer, Robert, Blankschtein, Daniel
Publié dans Nano Lett (2016)

Assessing siRNA Pharmacodynamics in a Luciferase-expressing Mouse

par Svensson, Robert U, Shey, Michael R, Ballas, Zuhair K, Dorkin, J Robert, Goldberg, Michael, Akinc, Akin, Langer, Robert, Anderson, Daniel G, Bumcrot, David, Henry, Michael D
Publié 2008

Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

par Kauffman, Kevin J., Oberli, Matthias A., Dorkin, J. Robert, Hurtado, Juan E., Kaczmarek, James C., Bhadani, Shivani, Wyckoff, Jeff, Langer, Robert, Jaklenec, Ana, Anderson, Daniel G.
Publié dans Mol Ther Nucleic Acids (2017)

Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent in vivo mRNA Delivery

par Fenton, Owen S., Kauffman, Kevin J., McClellan, Rebecca L., Appel, Eric A., Dorkin, J. Robert, Tibbitt, Mark W., Heartlein, Michael W., DeRosa, Frank, Langer, Robert, Anderson, Daniel G.
Publié dans Adv Mater (2016)

Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

par Dong, Yizhou, Dorkin, J. Robert, Wang, Weiheng, Chang, Philip H., Webber, Matthew J., Tang, Benjamin C., Yang, Junghoon, Abutbul-Ionita, Inbal, Danino, Dganit, DeRosa, Frank, Heartlein, Michael, Langer, Robert, Anderson, Daniel G.
Publié dans Nano Lett (2016)

Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

par Akinc, Akin, Goldberg, Michael, Qin, June, Dorkin, J Robert, Gamba-Vitalo, Christina, Maier, Martin, Jayaprakash, K Narayanannair, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Koteliansky, Victor, Röhl, Ingo, Leshchiner, Elizaveta S, Langer, Robert, Anderson, Daniel G
Publié 2009

Lipid-like Nanomaterials for simultaneous gene expression and silencing in vivo

par Dong, Yizhou, Eltoukhy, Ahmed A., Alabi, Christopher A., Khan, Omar F., Veiseh, Omid, Dorkin, J. Robert, Sirirungruang, Sasilada, Yin, Hao, Tang, Benjamin C., Pelet, Jeisa M., Chen, Delai, Gu, Zhen, Xue, Yuan, Langer, Robert, Anderson, Daniel G.
Publié 2014

Degradable Lipid Nanoparticles with Predictable In Vivo siRNA Delivery Activity

par Whitehead, Kathryn A., Dorkin, J. Robert, Vegas, Arturo J., Chang, Philip H., Veiseh, Omid, Matthews, Jonathan, Fenton, Owen S., Zhang, Yunlong, Olejnik, Karsten T., Yesilyurt, Volkan, Chen, Delai, Barros, Scott, Klebanov, Boris, Novobrantseva, Tatiana, Langer, Robert, Anderson, Daniel G.
Publié 2014

Lipid-like materials for low-dose, in vivo gene silencing

par Love, Kevin T., Mahon, Kerry P., Levins, Christopher G., Whitehead, Kathryn A., Querbes, William, Dorkin, J. Robert, Qin, June, Cantley, William, Qin, Liu Liang, Racie, Timothy, Frank-Kamenetsky, Maria, Yip, Ka Ning, Alvarez, Rene, Sah, Dinah W. Y., de Fougerolles, Antonin, Fitzgerald, Kevin, Koteliansky, Victor, Akinc, Akin, Langer, Robert, Anderson, Daniel G.
Publié 2010

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

par Akinc, Akin, Querbes, William, De, Soma, Qin, June, Frank-Kamenetsky, Maria, Jayaprakash, K. Narayanannair, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G, Cantley, William L, Dorkin, J Robert, Butler, James S, Qin, LiuLiang, Racie, Timothy, Sprague, Andrew, Fava, Eugenio, Zeigerer, Anja, Hope, Michael J, Zerial, Marino, Sah, Dinah WY, Fitzgerald, Kevin, Tracy, Mark A, Manoharan, Muthiah, Koteliansky, Victor, Fougerolles, Antonin de, Maier, Martin A
Publié 2010

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

par Dong, Yizhou, Love, Kevin T., Dorkin, J. Robert, Sirirungruang, Sasilada, Zhang, Yunlong, Chen, Delai, Bogorad, Roman L., Yin, Hao, Chen, Yi, Vegas, Arturo J., Alabi, Christopher A., Sahay, Gaurav, Olejnik, Karsten T., Wang, Weiheng, Schroeder, Avi, Lytton-Jean, Abigail K. R., Siegwart, Daniel J., Akinc, Akin, Barnes, Carmen, Barros, Scott A., Carioto, Mary, Fitzgerald, Kevin, Hettinger, Julia, Kumar, Varun, Novobrantseva, Tatiana I., Qin, June, Querbes, William, Koteliansky, Victor, Langer, Robert, Anderson, Daniel G.
Publié 2014

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

par Akinc, Akin, Zumbuehl, Andreas, Goldberg, Michael, Leshchiner, Elizaveta S, Busini, Valentina, Hossain, Naushad, Bacallado, Sergio A, Nguyen, David N, Fuller, Jason, Alvarez, Rene, Borodovsky, Anna, Borland, Todd, Constien, Rainer, de Fougerolles, Antonin, Dorkin, J Robert, Jayaprakash, K Narayanannair, Jayaraman, Muthusamy, John, Matthias, Koteliansky, Victor, Manoharan, Muthiah, Nechev, Lubomir, Qin, June, Racie, Timothy, Raitcheva, Denitza, Rajeev, Kallanthottathil G, Sah, Dinah W Y, Soutschek, Jürgen, Toudjarska, Ivanka, Vornlocher, Hans-Peter, Zimmermann, Tracy S, Langer, Robert, Anderson, Daniel G
Publié 2008