Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

Safe and effective delivery is required for siRNA and mRNA-based therapeutics to reach their potential. Here, we report on the development of poly(glycoamidoamine) brush nanoparticles as delivery vehicles for siRNA and mRNA. These polymers were capable of significant delivery of siRNA against FVII a...

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Bibliografiska uppgifter
I publikationen:Nano Lett
Huvudupphovsmän: Dong, Yizhou, Dorkin, J. Robert, Wang, Weiheng, Chang, Philip H., Webber, Matthew J., Tang, Benjamin C., Yang, Junghoon, Abutbul-Ionita, Inbal, Danino, Dganit, DeRosa, Frank, Heartlein, Michael, Langer, Robert, Anderson, Daniel G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278877/
https://ncbi.nlm.nih.gov/pubmed/26727632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.5b02428
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