Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

Safe and effective delivery is required for siRNA and mRNA-based therapeutics to reach their potential. Here, we report on the development of poly(glycoamidoamine) brush nanoparticles as delivery vehicles for siRNA and mRNA. These polymers were capable of significant delivery of siRNA against FVII a...

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Библиографические подробности
Опубликовано в: :Nano Lett
Главные авторы: Dong, Yizhou, Dorkin, J. Robert, Wang, Weiheng, Chang, Philip H., Webber, Matthew J., Tang, Benjamin C., Yang, Junghoon, Abutbul-Ionita, Inbal, Danino, Dganit, DeRosa, Frank, Heartlein, Michael, Langer, Robert, Anderson, Daniel G.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278877/
https://ncbi.nlm.nih.gov/pubmed/26727632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.5b02428
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