Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

Safe and effective delivery is required for siRNA and mRNA-based therapeutics to reach their potential. Here, we report on the development of poly(glycoamidoamine) brush nanoparticles as delivery vehicles for siRNA and mRNA. These polymers were capable of significant delivery of siRNA against FVII a...

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Publicat a:Nano Lett
Autors principals: Dong, Yizhou, Dorkin, J. Robert, Wang, Weiheng, Chang, Philip H., Webber, Matthew J., Tang, Benjamin C., Yang, Junghoon, Abutbul-Ionita, Inbal, Danino, Dganit, DeRosa, Frank, Heartlein, Michael, Langer, Robert, Anderson, Daniel G.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278877/
https://ncbi.nlm.nih.gov/pubmed/26727632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.5b02428
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