Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent in vivo mRNA Delivery

Thousands of human diseases could be treated by selectively controlling the expression of specific proteins in vivo. We demonstrate a new series of alkenyl amino alcohol (AAA) ionizable lipids that, when formulated into lipid nanoparticles (LNPs), are capable of delivering human mRNA with unpreceden...

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Bibliografiska uppgifter
I publikationen:Adv Mater
Huvudupphovsmän: Fenton, Owen S., Kauffman, Kevin J., McClellan, Rebecca L., Appel, Eric A., Dorkin, J. Robert, Tibbitt, Mark W., Heartlein, Michael W., DeRosa, Frank, Langer, Robert, Anderson, Daniel G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5245883/
https://ncbi.nlm.nih.gov/pubmed/26889757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.201505822
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