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Optimization of a Degradable Polymer-Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells
mRNA therapeutics hold great potential for treating a variety of diseases through protein-replacement, immunomodulation, and gene editing. However, much like siRNA therapy, the majority of progress in mRNA delivery has been confined to the liver. Previously, we demonstrated that poly(β-amino esters)...
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| Опубликовано в: : | Nano Lett |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6415675/ https://ncbi.nlm.nih.gov/pubmed/30211557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.8b02917 |
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