Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked

Por Wisastra, Rosalina, Dekker, Frank J.
Publicado em 2014

Histone acetyltransferases: challenges in targeting bi-substrate enzymes

Por Wapenaar, Hannah, Dekker, Frank J.
Publicado no Clin Epigenetics (2016)

The Process and Strategy for Developing Selective Histone Deacetylase 3 Inhibitors

Por Cao, Fangyuan, Zwinderman, Martijn R. H., Dekker, Frank J.
Publicado no Molecules (2018)

Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases

Por Dekker, Frank J., van den Bosch, Thea, Martin, Nathaniel I.
Publicado no Drug Discov Today (2011)

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation

Por Leus, Niek G.J., Zwinderman, Martijn R.H., Dekker, Frank J.
Publicado no Curr Opin Chem Biol (2016)

Metabolic alkene labeling and in vitro detection of histone acylation via the aqueous oxidative Heck reaction

Por Ourailidou, Maria E., Dockerty, Paul, Witte, Martin, Poelarends, Gerrit J., Dekker, Frank J.
Publicado no Org Biomol Chem (2015)

Light-controlled HDAC inhibitors: towards photopharmacological chemotherapy

Por Szymanski, Wiktor, Ourailidou, Maria E., Velema, Willem A., Dekker, Frank J., Feringa, Ben L.
Publicado no Chemistry (2015)

Towards the development of activity-based probes for detection of Lysine-Specific Demethylase-1 activity

Por Ourailidou, Maria E., Lenoci, Alessia, Zwergel, Clemens, Rotili, Dante, Mai, Antonello, Dekker, Frank J.
Publicado no Bioorg Med Chem (2016)

6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site

Por Ghizzoni, Massimo, Wu, Jiang, Gao, Tielong, Haisma, Hidde J., Dekker, Frank J., Zheng, Y. George
Publicado em 2011

The degradation of nucleotide triphosphates extracted under boiling ethanol conditions is prevented by the yeast cellular matrix

Por Gil, Andres, Siegel, David, Bonsing-Vedelaar, Silke, Permentier, Hjalmar, Reijngoud, Dirk-Jan, Dekker, Frank, Bischoff, Rainer
Publicado no Metabolomics (2016)

Activity-Based Probes for 15-lipoxygenase-1

Por Eleftheriadis, Nikolaos, Thee, Stephanie A., Zwinderman, Martijn R. H., Leus, Niek G. J., Dekker, Frank J.
Publicado no Angew Chem Int Ed Engl (2016)

Enzyme kinetics and inhibition of histone acetyltransferase KAT8

Por Wapenaar, Hannah, van der Wouden, Petra E., Groves, Matthew R., Rotili, Dante, Mai, Antonello, Dekker, Frank J.
Publicado no Eur J Med Chem (2015)

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

Por Xu, Jin, Hedberg, Christian, Dekker, Frank J., Li, Qing, Haigis, Kevin M., Hwang, Eugene, Waldmann, Herbert, Shannon, Kevin
Publicado em 2012

Site-specific quantification of lysine acetylation in the N-terminal tail of histone H4 using a double-labelling, targeted UHPLC MS/MS approach

Por D’Urzo, Annalisa, Boichenko, Alexander P., van den Bosch, Thea, Hermans, Jos, Dekker, Frank, Andrisano, Vincenza, Bischoff, Rainer
Publicado no Anal Bioanal Chem (2016)

Rational development of a potent 15-lipoxygenase-1 inhibitor with in vitro and ex vivo anti-inflammatory properties

Por Eleftheriadis, Nikolaos, Neochoritis, Constantinos G., Leus, Niek G.J., van der Wouden, Petra E., Dömling, Alexander, Dekker, Frank J.
Publicado no J Med Chem (2015)

Raft Protein Clustering Alters N-Ras Membrane Interactions and Activation Pattern

Por Eisenberg, Sharon, Beckett, Alison J., Prior, Ian A., Dekker, Frank J., Hedberg, Christian, Waldmann, Herbert, Ehrlich, Marcelo, Henis, Yoav I.
Publicado em 2011

Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection

Por Wisastra, Rosalina, Kok, Petra A.M, Eleftheriadis, Nikolaos, Baumgartner, Matthew P., Camacho, Carlos J., Haisma, Hidde J., Dekker, Frank J.
Publicado em 2013

Design of a novel Thiophene Inhibitor of 15-Lipoxygenase-1 with both Anti-inflammatory and Neuroprotective Properties

Por Eleftheriadis, Nikolaos, Poelman, Hessel, Leus, Niek G. J., Honrath, Birgit, Neochoritis, Constantinos G., Dolga, Amalia, Dömling, Alexander, Dekker, Frank J.
Publicado no Eur J Med Chem (2016)

Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans

Por Raj, Hans, Puthan Veetil, Vinod, Szymanski, Wiktor, Dekker, Frank J., Quax, Wim J., Feringa, Ben L., Janssen, Dick B., Poelarends, Gerrit J.
Publicado em 2011

A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices

Por van den Bosch, Thea, Leus, Niek G. J., Wapenaar, Hannah, Boichenko, Alexander, Hermans, Jos, Bischoff, Rainer, Haisma, Hidde J., Dekker, Frank J.
Publicado no Pulm Pharmacol Ther (2017)