Protease-Activated Receptor 1 as Therapeutic Target in Breast, Lung, and Ovarian Cancer: Pepducin Approach

par Covic, Lidija, Kuliopulos, Athan
Publié dans Int J Mol Sci (2018)

Pepducins and Other Lipidated Peptides as Mechanistic Probes and Therapeutics

par Zhang, Ping, Covic, Lidija, Kuliopulos, Athan
Publié dans Methods Mol Biol (2015)

Trace amine–associated receptor 1 (TAAR1) promotes anti-diabetic signaling in insulin-secreting cells

par Michael, Emily S., Covic, Lidija, Kuliopulos, Athan
Publié dans J Biol Chem (2019)

Turning Receptors On and Off with Intracellular Pepducins: New Insights into G-protein-coupled Receptor Drug Development

par O'Callaghan, Katie, Kuliopulos, Athan, Covic, Lidija
Publié 2012

Matrix metalloproteases and PAR1 activation

par Austin, Karyn M., Covic, Lidija, Kuliopulos, Athan
Publié 2013

Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides

par Covic, Lidija, Gresser, Amy L., Talavera, Joyce, Swift, Steven, Kuliopulos, Athan
Publié 2002

Noncanonical Matrix Metalloprotease-1-Protease-activated Receptor-1 Signaling Triggers Vascular Smooth Muscle Cell Dedifferentiation and Arterial Stenosis

par Austin, Karyn M., Nguyen, Nga, Javid, Golrokh, Covic, Lidija, Kuliopulos, Athan
Publié 2013

Pharmacology, Biodistribution, and Efficacy of GPCR-Based Pepducins in Disease Models

par Tressel, Sarah L., Koukos, Georgios, Tchernychev, Boris, Jacques, Suzanne L., Covic, Lidija, Kuliopulos, Athan
Publié 2011

Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins

par Sevigny, Leila M., Zhang, Ping, Bohm, Andrew, Lazarides, Katherine, Perides, George, Covic, Lidija, Kuliopulos, Athan
Publié 2011

Matrix Metalloprotease-1a Promotes Tumorigenesis and Metastasis

par Foley, Caitlin J., Luo, Chi, O'Callaghan, Katie, Hinds, Philip W., Covic, Lidija, Kuliopulos, Athan
Publié 2012

Identification of a metalloprotease-chemokine signaling system in the ovarian cancer microenvironment: implications for anti-angiogenic therapy

par Agarwal, Anika, Tressel, Sarah L., Kaimal, Rajani, Balla, Marianthi, Lam, Francis H., Covic, Lidija, Kuliopulos, Athan
Publié 2010

Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt-survival pathways in breast cancer cells and suppresses tumor survival and metastasis

par Yang, Eric, Boire, Adrienne, Agarwal, Anika, Nguyen, Nga, O'Callaghan, Katie, Tu, Powen, Kuliopulos, Athan, Covic, Lidija
Publié 2009

Bivalirudin is a Dual Inhibitor of Thrombin and Collagen-Dependent Platelet Activation in Patients Undergoing Percutaneous Coronary Intervention

par Kimmelstiel, Carey, Zhang, Ping, Kapur, Navin K., Weintraub, Andrew, Krishnamurthy, Barath, Castaneda, Vilma, Covic, Lidija, Kuliopulos, Athan
Publié 2011

Targeting a Metalloprotease-PAR1 Signaling System with Cell-Penetrating Pepducins Inhibits Angiogenesis, Ascites, and Progression of Ovarian Cancer

par Agarwal, Anika, Covic, Lidija, Sevigny, Leila M, Kaneider, Nicole C, Lazarides, Katherine, Azabdaftari, Gissou, Sharifi, Sheida, Kuliopulos, Athan
Publié 2008

A Novel Protease-activated Receptor-1 Interactor, Bicaudal D1, Regulates G Protein Signaling and Internalization

par Swift, Steven, Xu, Jian, Trivedi, Vishal, Austin, Karyn M., Tressel, Sarah L., Zhang, Lei, Covic, Lidija, Kuliopulos, Athan
Publié 2010

‘Role reversal’ for the receptor PAR1 in sepsis-induced vascular damage

par Kaneider, Nicole C, Leger, Andrew J, Agarwal, Anika, Nguyen, Nga, Perides, George, Derian, Claudia, Covic, Lidija, Kuliopulos, Athan
Publié 2007

PAR2 modulates PAR1-driven neointimal hyperplasia

par Sevigny, Leila M., Austin, Karyn M., Zhang, Ping, Kasuda, Shogo, Koukos, Georgios, Sharifi, Sheida, Covic, Lidija, Kuliopulos, Athan
Publié 2011

Targeting Liver Fibrosis with a Cell-penetrating Protease-activated Receptor-2 (PAR2) Pepducin

par Shearer, Andrew M., Rana, Rajashree, Austin, Karyn, Baleja, James D., Nguyen, Nga, Bohm, Andrew, Covic, Lidija, Kuliopulos, Athan
Publié dans J Biol Chem (2016)

Lipid Receptor GPR31 (G-Protein–Coupled Receptor 31) Regulates Platelet Reactivity and Thrombosis Without Affecting Hemostasis

par Van Doren, Layla, Nguyen, Nga, Garzia, Christopher, Fletcher, Elizabeth K., Stevenson, Ryan, Jaramillo, David, Kuliopulos, Athan, Covic, Lidija
Publié dans Arterioscler Thromb Vasc Biol (2020)

Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis By Activating PAR1 at a Cryptic Ligand Site

par Trivedi, Vishal, Boire, Adrienne, Tchernychev, Boris, Kaneider, Nicole C., Leger, Andrew J., O’Callaghan, Katie, Covic, Lidija, Kuliopulos, Athan
Publié 2009