Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins

Protease-activated receptor-2 (PAR2), a cell surface receptor for trypsin-like proteases, plays a key role in a number of acute and chronic inflammatory diseases of the joints, lungs, brain, gastrointestinal tract, and vascular systems. Despite considerable effort by the pharmaceutical industry, PAR...

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Bibliographic Details
Main Authors: Sevigny, Leila M., Zhang, Ping, Bohm, Andrew, Lazarides, Katherine, Perides, George, Covic, Lidija, Kuliopulos, Athan
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100971/
https://ncbi.nlm.nih.gov/pubmed/21536878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017091108
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