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A Novel Protease-activated Receptor-1 Interactor, Bicaudal D1, Regulates G Protein Signaling and Internalization
Protease-activated receptor-1 (PAR1) is a G protein-coupled receptor that plays critical roles in cancer, angiogenesis, inflammation, and thrombosis. Proteolytic cleavage of the extracellular domain of PAR1 generates a tethered ligand that activates PAR1 in an unusual intramolecular mode. The signal...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857018/ https://ncbi.nlm.nih.gov/pubmed/20164183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.105403 |
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