A Novel Protease-activated Receptor-1 Interactor, Bicaudal D1, Regulates G Protein Signaling and Internalization

Protease-activated receptor-1 (PAR1) is a G protein-coupled receptor that plays critical roles in cancer, angiogenesis, inflammation, and thrombosis. Proteolytic cleavage of the extracellular domain of PAR1 generates a tethered ligand that activates PAR1 in an unusual intramolecular mode. The signal...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Swift, Steven, Xu, Jian, Trivedi, Vishal, Austin, Karyn M., Tressel, Sarah L., Zhang, Lei, Covic, Lidija, Kuliopulos, Athan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Signal Transduction
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857018/
https://ncbi.nlm.nih.gov/pubmed/20164183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.105403
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