Hypoxia Stimulates Hepatocyte Epithelial to Mesenchymal Transition by Hypoxiainducible Factor- and Transforming Growth Factor-β-dependent Mechanisms

Por Copple, Bryan L.
Publicado em 2010

Pharmacology of Bile Acid Receptors: Evolution of Bile Acids from Simple Detergents to Complex Signaling Molecules

Por Copple, Bryan L., Li, Tiangang
Publicado no Pharmacol Res (2015)

Role of Hypoxia-Inducible Factors in the Development of Liver Fibrosis

Por Roth, Katherine J., Copple, Bryan L.
Publicado no Cell Mol Gastroenterol Hepatol (2015)

Bile Acids Induce Inflammatory Genes in Hepatocytes: A Novel Mechanism of Inflammation during Obstructive Cholestasis

Por Allen, Katryn, Jaeschke, Hartmut, Copple, Bryan L.
Publicado em 2011

Hypoxia-Inducible Factor Activation in Myeloid Cells Contributes to the Development of Liver Fibrosis in Cholestatic Mice

Por Copple, Bryan L., Kaska, Sophia, Wentling, Callie
Publicado em 2012

Hypoxia-inducible Factor-dependent Production of Profibrotic Mediators by Hypoxic Kupffer Cells

Por Copple, Bryan L., Bai, Shan, Moon, Jeon-OK
Publicado em 2010

Upregulation of Early Growth Response Factor-1 by Bile Acids Requires Mitogen-activated Protein Kinase Signaling

Por Allen, Katryn, Kim, Nam Deuk, Moon, Jeon-OK, Copple, Bryan L.
Publicado em 2009

Hypoxia-inducible Factor-1α Regulates Expression of Genes in Hypoxic Hepatic Stellate Cells Important for Collagen Deposition and Angiogenesis

Por Copple, Bryan L., Bai, Shan, Burgoon, Lyle D., Moon, Jeon-OK
Publicado em 2010

Early Growth Response Factor-1 Limits Biliary Fibrosis in a Model of Xenobiotic-Induced Cholestasis in Mice

Por Sullivan, Bradley P., Cui, Wei, Copple, Bryan L., Luyendyk, James P.
Publicado em 2012

Gene Profiling of Maternal Hepatic Adaptations to Pregnancy

Por Bustamante, Juan J., Copple, Bryan L., Soares, Michael J., Dai, Guoli
Publicado no Liver Int (2009)

Reduced liver fibrosis in hypoxia-inducible factor-1α-deficient mice

Por Moon, Jeon-OK, Welch, Timothy P., Gonzalez, Frank J., Copple, Bryan L.
Publicado em 2009

The Transition from Fatty Liver to NASH Associates with SAMe Depletion in db/db Mice Fed a Methionine Choline-Deficient Diet

Por Wortham, Matthew, He, Lin, Gyamfi, Maxwell, Copple, Bryan L., Yvonne Wan, Yu-Jui
Publicado em 2008

Therapeutic Administration of the Direct Thrombin Inhibitor Argatroban Reduces Hepatic Inflammation in Mice with Established Fatty Liver Disease

Por Kassel, Karen M., Sullivan, Bradley P., Cui, Wei, Copple, Bryan L., Luyendyk, James P.
Publicado em 2012

Tissue factor-dependent coagulation contributes to α-naphthylisothiocyanate-induced cholestatic liver injury in mice

Por Luyendyk, James P., Cantor, Glenn H., Kirchhofer, Daniel, Mackman, Nigel, Copple, Bryan L., Wang, Ruipeng
Publicado em 2009

Hypoxia-inducible Factor-dependent Production of Profibrotic Mediators by Hypoxic Hepatocytes

Por Copple, Bryan L., Bustamante, Juan J., Welch, Timothy P., Kim, Nam Deuk, Moon, Jeon-OK
Publicado em 2009

E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr-1/SHP/EID1 network

Por Zhang, Yuxia, Xu, Ningyi, Xu, Jun, Kong, Bo, Copple, Bryan, Guo, Grace L., Wang, Li
Publicado em 2014

EFFECT OF BILE DUCT LIGATION ON BILE ACID COMPOSITION IN MOUSE SERUM AND LIVER

Por Zhang, Youcai, Hong, Ji-Young, Rockwell, Cheryl E., Copple, Bryan L., Jaeschke, Hartmut, Klaassen, Curtis D.
Publicado em 2011

IL-17A Synergistically Enhances Bile Acid–Induced Inflammation during Obstructive Cholestasis

Por O'Brien, Kate M., Allen, Katryn M., Rockwell, Cheryl E., Towery, Keara, Luyendyk, James P., Copple, Bryan L.
Publicado em 2013

Role of Hypoxia Inducing Factor-1β in Alcohol-Induced Autophagy, Steatosis and Liver Injury in Mice

Por Ni, Hong-Min, Bhakta, Amar, Wang, Shaogui, Li, Zhenrui, Manley, Sharon, Huang, Heqing, Copple, Bryan, Ding, Wen-Xing
Publicado no PLoS One (2014)

Fibrinogen Deficiency Increases Liver Injury and Early Growth Response-1 (Egr-1) Expression in a Model of Chronic Xenobiotic-Induced Cholestasis

Por Luyendyk, James P., Kassel, Karen M., Allen, Katryn, Guo, Grace L., Li, Guodong, Cantor, Glenn H., Copple, Bryan L.
Publicado em 2011