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Reduced liver fibrosis in hypoxia-inducible factor-1α-deficient mice

Liver fibrosis is characterized by excessive deposition of extracellular matrix in the liver during chronic injury. During early stages of this disease, cells begin to synthesize and secrete profibrotic proteins that stimulate matrix production and inhibit matrix degradation. Although it is clear th...

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Autores principales: Moon, Jeon-OK, Welch, Timothy P., Gonzalez, Frank J., Copple, Bryan L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660171/
https://ncbi.nlm.nih.gov/pubmed/19136383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90368.2008
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