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Tissue factor-dependent coagulation contributes to α-naphthylisothiocyanate-induced cholestatic liver injury in mice

Separation of concentrated bile acids from hepatic parenchymal cells is a key function of the bile duct epithelial cells (BDECs) that form intrahepatic bile ducts. Using coimmunostaining, we found that tissue factor (TF), the principal activator of coagulation, colocalized with cytokeratin 19, a mar...

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Detalhes bibliográficos
Main Authors: Luyendyk, James P., Cantor, Glenn H., Kirchhofer, Daniel, Mackman, Nigel, Copple, Bryan L., Wang, Ruipeng
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670671/
https://ncbi.nlm.nih.gov/pubmed/19179621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90639.2008
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