Tissue factor-dependent coagulation contributes to α-naphthylisothiocyanate-induced cholestatic liver injury in mice

Separation of concentrated bile acids from hepatic parenchymal cells is a key function of the bile duct epithelial cells (BDECs) that form intrahepatic bile ducts. Using coimmunostaining, we found that tissue factor (TF), the principal activator of coagulation, colocalized with cytokeratin 19, a mar...

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Hlavní autoři: Luyendyk, James P., Cantor, Glenn H., Kirchhofer, Daniel, Mackman, Nigel, Copple, Bryan L., Wang, Ruipeng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2009
Témata:
Liver and Biliary Tract
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670671/
https://ncbi.nlm.nih.gov/pubmed/19179621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90639.2008
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