Role of Fibrinogen and Protease-Activated Receptors in Acute Xenobiotic-Induced Cholestatic Liver Injury

Alpha-naphthylisothiocyanate (ANIT)–induced cholestatic liver injury causes tissue factor (TF)–dependent coagulation in mice, and TF deficiency reduces ANIT-induced liver injury. However, the mechanism whereby TF contributes to hepatotoxicity in this model is not known. Utilizing pharmacological and...

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Autors principals: Luyendyk, James P., Mackman, Nigel, Sullivan, Bradley P.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
Systems Toxicology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003835/
https://ncbi.nlm.nih.gov/pubmed/20974703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq327
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