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Protective and Damaging Effects of Platelets in Acute Cholestatic Liver Injury Revealed by Depletion and Inhibition Strategies

Alpha-naphthylisothiocyanate (ANIT) causes cholestatic hepatitis characterized by intrahepatic bile duct epithelial cell injury and periportal hepatocellular necrosis. The progression of ANIT-induced hepatocyte injury is reported to involve extrahepatic cells including platelets. We showed recently...

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Detalles Bibliográficos
Main Authors: Sullivan, Bradley P., Wang, Ruipeng, Tawfik, Ossama, Luyendyk, James P.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855361/
https://ncbi.nlm.nih.gov/pubmed/20133375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq042
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