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Early Growth Response Factor-1 Limits Biliary Fibrosis in a Model of Xenobiotic-Induced Cholestasis in Mice
Hepatic expression of the transcription factor early growth response-1 (Egr-1) is increased in livers of patients with cholestatic liver disease. Bile acid induction of inflammatory genes in hepatocytes is Egr-1 dependent, and Egr-1 expression is increased in livers of mice after bile duct ligation....
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3289494/ https://ncbi.nlm.nih.gov/pubmed/22094456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr311 |
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