Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice

Acetaminophen (APAP)-induced liver injury in humans is associated with robust coagulation cascade activation and thrombocytopenia. However, it is not known whether coagulation-driven platelet activation participates in APAP hepatotoxicity. Here, we found that APAP overdose in mice caused liver damag...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Miyakawa, Kazuhisa, Joshi, Nikita, Sullivan, Bradley P., Albee, Ryan, Brandenberger, Christina, Jaeschke, Hartmut, McGill, Mitchell R., Scott, Michael A., Ganey, Patricia E., Luyendyk, James P., Roth, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600019/
https://ncbi.nlm.nih.gov/pubmed/26179083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-09-598656
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