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Inhibition of PAR-4 and P2Y(12) receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease
Emerging evidence supports a protective effect of platelets in experimental cholestatic liver injury and cholangiofibrosis. Coagulation-mediated platelet activation has been shown to inhibit experimental chronic cholestatic liver necrosis and biliary fibrosis. This occurs through thrombin-mediated a...
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| Veröffentlicht in: | Toxicology |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5091088/ https://ncbi.nlm.nih.gov/pubmed/27475285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2016.07.021 |
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