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Hypoxia Stimulates Hepatocyte Epithelial to Mesenchymal Transition by Hypoxiainducible Factor- and Transforming Growth Factor-β-dependent Mechanisms
BACKGROUND/AIMS: During development of liver fibrosis, an important source of myofibroblasts is hepatocytes, which differentiate into myofibroblasts by epithelial to mesenchymal transition (EMT). In epithelial tumors and kidney fibrosis, hypoxia, through activation of hypoxia-inducible factors (HIFs...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3111074/ https://ncbi.nlm.nih.gov/pubmed/20158611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1478-3231.2010.02205.x |
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