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Hypoxia Stimulates Hepatocyte Epithelial to Mesenchymal Transition by Hypoxiainducible Factor- and Transforming Growth Factor-β-dependent Mechanisms

BACKGROUND/AIMS: During development of liver fibrosis, an important source of myofibroblasts is hepatocytes, which differentiate into myofibroblasts by epithelial to mesenchymal transition (EMT). In epithelial tumors and kidney fibrosis, hypoxia, through activation of hypoxia-inducible factors (HIFs...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awdur: Copple, Bryan L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111074/
https://ncbi.nlm.nih.gov/pubmed/20158611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1478-3231.2010.02205.x
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