IL-17A Synergistically Enhances Bile Acid–Induced Inflammation during Obstructive Cholestasis

During obstructive cholestasis, increased concentrations of bile acids activate ERK1/2 in hepatocytes, which up-regulates early growth response factor 1, a key regulator of proinflammatory cytokines, such as macrophage inflammatory protein 2 (MIP-2), which, in turn, exacerbates cholestatic liver inj...

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Detalhes bibliográficos
Main Authors: O'Brien, Kate M., Allen, Katryn M., Rockwell, Cheryl E., Towery, Keara, Luyendyk, James P., Copple, Bryan L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814525/
https://ncbi.nlm.nih.gov/pubmed/24012680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.07.019
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