OSTEOPONTIN IS AN INITIAL MEDIATOR OF INFLAMMATION AND LIVER INJURY DURING OBSTRUCTIVE CHOLESTASIS AFTER BILE DUCT LIGATION IN MICE

Osteopontin (OPN) is a chemotactic factor which can be cleaved to the pro-inflammatory form by matrix metalloproteinases (MMPs). To test the hypothesis that OPN can modulate inflammatory liver injury during cholestasis, wild-type (WT) C57BL/6 and OPN knockout (OPN-KO) mice underwent bile duct ligati...

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Detalhes bibliográficos
Main Authors: Yang, Min, Ramachandran, Anup, Yan, Hui-Min, Woolbright, Benjamin L., Copple, Bryan L., Fickert, Peter, Trauner, Michael, Jaeschke, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875222/
https://ncbi.nlm.nih.gov/pubmed/24188933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2013.10.030
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