Collaborating Pathways that Functionally Amplify NOTCH1 Signals in T-Cell Acute Lymphoblastic Leukemia

Por Pinnell, Nancy E., Chiang, Mark Y.
Publicado no J Hematol Transfus (2013)

Oncogenic Notch signaling in T and B cell lymphoproliferative disorders

Por Chiang, Mark Y., Radojcic, Vedran, Maillard, Ivan
Publicado no Curr Opin Hematol (2016)

Transient Responses to NOTCH and TLX1/HOX11 Inhibition in T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Por Rakowski, Lesley A., Lehotzky, Erica A., Chiang, Mark Y.
Publicado em 2011

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells

Por Chiang, Mark Y., Shestova, Olga, Xu, Lanwei, Aster, Jon C., Pear, Warren S.
Publicado em 2013

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia

Por Chiang, Mark Y., Wang, Qing, Gormley, Anna C., Stein, Sarah J., Xu, Lanwei, Shestova, Olga, Aster, Jon C., Pear, Warren S.
Publicado no Blood (2016)

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1

Por Ashworth, Todd D., Pear, Warren S., Chiang, Mark Y., Blacklow, Stephen C., Mastio, Jérôme, Xu, Lanwei, Kelliher, Michelle, Kastner, Philippe, Chan, Susan, Aster, Jon C.
Publicado em 2010

Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias

Por Rakowski, Lesley A., Garagiola, Derek D., Li, Choi M., Decker, Margaret, Caruso, Sarah, Jones, Morgan, Kuick, Rork, Cierpicki, Tomasz, Maillard, Ivan, Chiang, Mark Y.
Publicado em 2012

Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1

Por Chiang, Mark Y., Xu, Mina L., Histen, Gavin, Shestova, Olga, Roy, Monideepa, Nam, Yunsun, Blacklow, Stephen C., Sacks, David B., Pear, Warren S., Aster, Jon C.
Publicado em 2006

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras–initiated leukemia

Por Chiang, Mark Y., Xu, Lanwei, Shestova, Olga, Histen, Gavin, L’Heureux, Sarah, Romany, Candice, Childs, M. Eden, Gimotty, Phyllis A., Aster, Jon C., Pear, Warren S.
Publicado em 2008

Co-deletion of the Ras GTPase-activating proteins Neurofibromin 1 (NF1) and p120 RasGAP (RASA1) in T cells results in the development of T cell acute lymphoblastic leukemia

Por Lubeck, Beth A., Lapinski, Philip E., Oliver, Jennifer A., Ksionda, Olga, Parada, Luis F., Zhu, Yuan, Maillard, Ivan, Chiang, Mark, Roose, Jeroen, King, Philip D.
Publicado no J Immunol (2015)

Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A

Por Yashiro-Ohtani, Yumi, He, Yiping, Ohtani, Takuya, Jones, Mary E., Shestova, Olga, Xu, Lanwei, Fang, Terry C., Chiang, Mark Y., Intlekofer, Andrew M., Blacklow, Stephen C., Zhuang, Yuan, Pear, Warren S.
Publicado em 2009

Notch dimerization is required for leukemogenesis and T-cell development

Por Liu, Hudan, Chi, Anthony W.S., Arnett, Kelly L., Chiang, Mark Y., Xu, Lanwei, Shestova, Olga, Wang, Hongfang, Li, Yue-Ming, Bhandoola, Avinash, Aster, Jon C., Blacklow, Stephen C., Pear, Warren S.
Publicado em 2010

PKCθ Regulates T-Cell Leukemia-Initiating Activity via Reactive Oxygen Species

Por Giambra, Vincenzo, Jenkins, Christopher R., Wang, Hongfang, Lam, Sonya H., Shevchuk, Olena O., Nemirovsky, Oksana, Wai, Carol, Gusscott, Sam, Chiang, Mark Y., Aster, Jon C., Humphries, R. Keith, Eaves, Connie, Weng, Andrew P.
Publicado em 2012

The PIAS-like coactivator Zmiz1 is a direct and selective cofactor of Notch1 in T-cell development and leukemia

Por Pinnell, Nancy, Yan, Ran, Cho, Hyo Je, Keeley, Theresa, Murai, Marcelo J., Liu, Yiran, Alarcon, Amparo Serna, Qin, Jason, Wang, Qing, Kuick, Rork, Elenitoba-Johnson, Kojo S.J., Maillard, Ivan, Samuelson, Linda C., Cierpicki, Tomasz, Chiang, Mark Y.
Publicado no Immunity (2015)

Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma

Por Kiel, Mark J., Velusamy, Thirunavukkarasu, Betz, Bryan L., Zhao, Lili, Weigelin, Helmut G., Chiang, Mark Y., Huebner-Chan, David R., Bailey, Nathanael G., Yang, David T., Bhagat, Govind, Miranda, Roberto N., Bahler, David W., Medeiros, L. Jeffrey, Lim, Megan S., Elenitoba-Johnson, Kojo S.J.
Publicado em 2012

Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development

Por Wang, Qing, Yan, Ran, Pinnell, Nancy, McCarter, Anna C., Oh, Yeonjoo, Liu, Yiran, Sha, Cher, Garber, Noah F., Chen, Yitong, Wu, Qingqing, Ku, Chia-Jui, Tran, Ivy, Serna Alarcon, Amparo, Kuick, Rork, Engel, James Douglas, Maillard, Ivan, Cierpicki, Tomasz, Chiang, Mark Y.
Publicado no Blood (2018)