PKCθ Regulates T-Cell Leukemia-Initiating Activity via Reactive Oxygen Species

Reactive oxygen species (ROS), a by-product of cellular metabolism, damage intracellular macromolecules and, in excess, can promote normal hematopoietic stem cell differentiation and exhaustion(1–3). However, mechanisms that regulate ROS levels in leukemia-initiating cells (LICs) and the biological...

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Detalhes bibliográficos
Main Authors: Giambra, Vincenzo, Jenkins, Christopher R., Wang, Hongfang, Lam, Sonya H., Shevchuk, Olena O., Nemirovsky, Oksana, Wai, Carol, Gusscott, Sam, Chiang, Mark Y., Aster, Jon C., Humphries, R. Keith, Eaves, Connie, Weng, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738873/
https://ncbi.nlm.nih.gov/pubmed/23086478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2960
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