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Intervention of PKC-θ as an immunosuppressive regimen
PKC-θ is selectively enriched in T cells and specifically translocates to immunological synapse where it mediates critical T cell receptor signals required for T cell activation, differentiation, and survival. T cells deficient in PKC-θ are defective in their ability to differentiate into inflammato...
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Research Foundation
2012
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3410430/ https://ncbi.nlm.nih.gov/pubmed/22876242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2012.00225 |
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