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Differential requirement of PKC-θ in the development and function of Natural Regulatory T cells
CD4+CD25+ natural Treg cells, which are developed in the thymus, migrate to the periphery to actively maintain self-tolerance. Similar to conventional T cells, TCR signals are critical for the development and activation of Treg cell inhibitory function. While PKC-θ-mediated TCR signals are required...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2700121/ https://ncbi.nlm.nih.gov/pubmed/18842300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2008.08.275 |
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