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PKC-θ inhibits iTreg differentiation via an AKT-FoxO1/3a-dependent pathway
Protein Kinase C-θ (PKC-θ) has been shown to be a critical T cell receptor (TCR) signaling molecule that promotes the activation and differentiation of naïve T cells into inflammatory effector T cells. We demonstrate here that PKC-θ-mediated signals inhibit iTreg differentiation via an AKT-Forkhead...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3484896/ https://ncbi.nlm.nih.gov/pubmed/22539794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102979 |
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